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Workshop Descriptions

 

52-01 Basics of Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents

Saturday, September 8 | 8:30 a.m. - 12:00 p.m.

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by academia, industry and regulatory agencies there is presently a lack of training into these disciplines. The aim is to train people professionally involved in development or in the use of anti-infective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 20 years and how their influence has grown. 

Upon completion of this workshop, the participant should be able to: 

• Identify pharmacokinetic and pharmacodynamic concepts of antimicrobial efficacy; 
• Apply in vitro models and animal models in pharmacodynamic research; 
• Recognize the limitations and use of serum and tissue concentrations; 
• Calculate pharmacokinetic and pharmacodynamic parameters and interpret the results; and 
• Assess drug resistance in vitro.

52-02 Clinical Relevance of Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents

Saturday, September 8 |1:00 p.m. - 4:30 p.m.

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by academia, industry and regulatory, there is presently a lack of training into these disciplines. The aim is to train people professionally involved in development or in the use of anti-infective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 20 years and how their influence has grown. 

Upon completion of this workshop, the participant should be able to: 

• Gain insight in the clinical significance of Pharmacokinetics and Pharmacodynamics modeling of antimicrobials; 
• Extrapolate preclinical Pharmacokinetics and Pharmacodynamics information into clinical drug development; 
• Determine Pharmacokinetics and Pharmacodynamics of antibacterials and antifungals; 
• Assess drug exposure at the site of infection; and 
• Recognize and evaluate clinical drug resistance.

52-03 Introduction to Pharmacokinetics and Pharmacodynamics  Modeling of Anti-Infective Agents

Saturday, September 8 |8:30 a.m. - 12:00 p.m.

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by academia, industry and regulatory agencies, there is presently a lack of training into these disciplines. The aim is to train scientists and health professionals involved in development or in the use of anti-infective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 20 years and how their influence has grown. 

Upon completion of this workshop, the participant should be able to: 

• Apply MIC based Pharmacokinetics and Pharmacodynamics modeling in vitro and in animals; 
• Perform Pharmacokinetics and Pharmacodynamics analysis based on kill curves; 
• Employ population Pharmacokinetics and Pharmacodynamics of anti-infective agents; 
• Design and evaluate Monte Carlo Simulations; and 
• Integrate preclinical and clinical Pharmacokinetics and Pharmacodynamics.

52-04 Advanced Pharmacokinetics and Pharmacodynamics  Modeling of Anti-Infective Agents with Practical Examples

Saturday, September 8 |1:00 p.m. - 4:30 p.m.

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by academia, industry and regulatory agencies, there is presently a lack of training into these disciplines. The aim is to train people professionally involved in development or in the use of anti-infective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 20 years and how their influence has grown. 

Upon completion of this workshop, the participant should be able to: 

• Employ sophisticated kill curve modeling; 
• Design Pharmacokinetics and Pharmacodynamics models to predict and avoid resistance development; 
• Integrate modeling and simulation in to the overall drug development activities; and 
• Identify the integration of preclinical and clinical Pharmacokinetics and Pharmacodynamics to streamline decision making in drug development.

52-05 Pharmacokinetics and Pharmacodynamics Full-Day Workshop Combining 52-01 and 52-02

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

See descriptions 52-01 and 52-02.  

52-06 Pharmacokinetics and Pharmacodynamics Full-Day Workshop Combining 52-03 and 52-04

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

See descriptions 52-03 and 52-04.

52-07 Pharmacokinetics and Pharmacodynamics Full-Day Workshop Combining 52-04 and 52-01

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

See descriptions 52-04 and 52-01.

52-08 Pharmacokinetics and Pharmacodynamics Full-Day Workshop Combining 52-03 and 52-02

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

See descriptions 52-03 and 52-02.

52-10 Antibiotic Resistance Among Bacterial Pathogens: Mechanisms, Detection, and Molecular Epidemiology

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

This intermediate level workshop will address important mechanisms of antibiotic resistance among common bacterial pathogens (VISA, hVISA, MRSA, ESBLs including CTX-M enzymes, amp(C), carbapenem-resistant Enterobacteriaceae mediated by KPCs, metallo-beta-lactamases, etc.). In addition, the rapidly improving test menus for Clostridium difficile will be reviewed as well as new treatments and CDC guidelines. The workshop will also explain the mechanisms of resistance for selected classes of antibiotics as well as the PK/PD parameters of these compounds that assist in evaluating potential clinical efficacy. The workshop will also include a discussion of applications and methodologies for molecular epidemiologic typing of bacteria, highlighted with examples.

Upon completion of this workshop, the participant should be able to:

• Describe the nuances and problems associated with susceptibility testing of staphylococci;
• Recognize the problems associated with detection of antibiotic resistance in Enterobacteriaceae and other gram-negative pathogens, and methods employed to overcome such difficulties; 
• Detect Clostridium difficile with significantly increased accuracy; 
• Describe how to use molecular typing tools in the clinical laboratory to solve epidemiologic problems; and 
• Explain the Pharmacokinetics and Pharmacodynamics parameters used to evaluate antimicrobial agents in the light of evolving resistance.

 

52-11 Antimicrobial Stewardship in Hospitals

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

This workshop will provide the theoretical foundation and the practical information and tools to develop a hospital Antimicrobial Stewardship program. The focus will be on measuring, evaluating and managing antimicrobial use, and on strategies to cost-justify the program. The morning session includes methods for data collection, analysis and interpretation of antimicrobial consumption data in the individual hospital, as well as within multicenter networks. The afternoon session presents strategies from successful antimicrobial management programs, methods to audit the quality of antimicrobial prescriptions, a critical review of different intervention strategies to improve antimicrobial use in health care facilities and the role of newer information technology to help improve antimicrobial drug use. 

Upon completion of this workshop, the participant should be able to: 

• Select proper measurement units to describe the volume of antimicrobial use; 
• Interpret antimicrobial use data locally and within a multicenter network (Benchmarking); 
• Choose and to apply an audit methodology for monitoring the quality of antimicrobial prescriptions; 
• Identify possible intervention strategies and their relative advantages and disadvantages and which could be implemented in a hospital; 
• Identify the electronic antimicrobial drug prescribing aids and the advantages and disadvantages of each; 
• Describe how an individual hospital can determine if its antimicrobial management program was economically successful and if it had an impact on bacterial resistance; 
• Describe the use of biomarkers of infection that may be useful to guide the duration of therapy; and 
• Describe the elements needed to launch a stewardship program in community hospitals.

52-12 A Year in Review: Critical Analysis and Application of Treatment Guidelines for Infectious Diseases

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

Description to be determined.

 

52-13 New Clinical Microbiology Diagnostics: What is or Could be in Your Lab?

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.

In this workshop, a number of modern clinical microbiology technologies available for today’s laboratories will be discussed. Technologies to be highlighted will range from matrix assisted laser desorption ionization mass spectrometry to molecular genetic approaches, with a focus on a number of commercially available newer platforms. Strengths and limitations of the technologies, including laboratory workflow issues, and cost/cost-savings will be highlighted. The faculty will be laboratorians with experience in using these new technologies in their own laboratories. There will be plenty of opportunity for discussion. 

Upon completion of this workshop, the participant should be able to: 

• State the potential benefits to patient care (if any) realized by adopting the discussed technologies; 
  Discuss the strengths and limitations of the discussed diagnostic tests; 
• Apply the discussed diagnostic techniques to their clinical practice; and 
• Assess workflow changes, if any, surrounding use of these new technologies.

52-14 Transplant Infectious Diseases: Prevention and Resistance: Challenges for the 21st Century

Saturday, September 8 | 8:30 a.m. - 4:30 p.m.
Developed in cooperation with the International Society of Heart and Lung Transplantation (ISHLT).

This workshop is designed to update attendees on current practices in transplantation, including the use of guidelines for patient management. Prevention of common infections will be reviewed. The role of infection control in prevention will also be discussed. Finally the management of difficult to treat infections, including resistant herpes viruses and bacteria, respiratory viruses and non-tuberculosis mycobacteria will be discussed.

Upon completion of this workshop, the participant should be able to: 

• Determine the impact of antimicrobials on prevention of infection; 
• Identify adjunctive prevention strategies, including immunization and infection control strategies; 
• Appraise the impact of viral infections on transplant outcomes; and 
• Assess issues related to diagnosis and treatment for multiple difficult to treat infections in transplant recipients, including resistant viruses, bacteria and mycobacteria.

For questions regarding the workshops, please contact This e-mail address is being protected from spambots. You need JavaScript enabled to view it. .