This useful, compact report contains official highlights from the 51st ICAAC in Chicago, Illinois, USA. In this edition, you will find peer-reviewed articles summarizing key trials on MRSA interventions, antibiotic therapy for lower respiratory tract infections, and the effectiveness of aP vaccine in pre-adolescents. Therapeutic updates include research on new antiretroviral agents and novel regimens for fighting HIV, hot topics in vaccines, and preventing antiobiotic resistance.